Given that I’ve had no problem installing EndeavoursOS (an Arch-based OS), I would presume that installing any other RPi5 supporting distro should be fine. (Fedora seems to have RPi5 installation images here though I am not a Fedora user so don’t blindly trust me on that).
The only things which are ONE-up specific are the battery (I use this installed/compiled using DKMS and deployed using dtoverlay) and the lid open/close (I use that dtoverlay), everything else is either generic for all RPi5s (RPi5, CM5, RP 500, etc.) (like display, 3D acceleration, fan control, GPIO, etc.) or plug’n’play (like USB hubs, keyboard, touchpad, etc.).